What AOD-9604 is
AOD-9604 is a peptide of 16 amino acids. FDA's review describes it as a synthetic fragment of human growth hormone, amino acids 177 to 191, with one extra tyrosine added at the front. It gives the formula of the free base as C78H123N23O23S2 and its molecular weight as 1,815.09 g/mol.
Where it stands with the FDA
AOD-9604 isn't approved by the FDA, and the agency says it isn't a component of any FDA-approved drug. It was nominated for compounding, the nominations were withdrawn, and FDA reviewed it on its own initiative.
The review evaluated it for obesity and concluded that the criteria weigh against putting it on the list of substances pharmacies may compound with.
On December 4, 2024, FDA's Pharmacy Compounding Advisory Committee voted on it. Nobody voted in favor and 12 voted against.
The strength in the record
The nominations described three products: an injection under the skin at 1,200 mcg/mL, a 600 mcg capsule and a cream. Only the injection involves any vial math.
| Strength in the record | Water for a 5 mg vial | One unit holds | 10 units hold |
|---|---|---|---|
| 1,200 mcg/mL | 4.167 mL | 12 mcg | 120 mcg |
Add that much water to a 5 mg vial and it comes to that strength. Any other amount of water works too. It only changes how many units the same dose takes up.
Storing AOD-9604
FDA's review gives -20°C as the recommended storage temperature for the acetate form, and says it's reported to be stable for more than four years stored that way. That describes the dry substance, not a mixed vial.
There's no approved label for AOD-9604, so nothing official says how long a mixed vial keeps.
AOD-9604 dosage calculator questions
How do I turn a AOD-9604 dose into syringe units?
Divide the dose by the concentration to get millilitres, then multiply by 100. A 5 mg vial mixed with 2 mL is 2.5 mg/mL, so one unit on an insulin syringe holds 25 mcg and ten units hold 250 mcg.
How much bacteriostatic water goes in a 5 mg vial of AOD-9604?
There's no single right amount. The water only sets the concentration, and the amount of AOD-9604 in the vial stays the same. With 5 mg, 1 mL makes 5 mg/mL, 2 mL makes 2.5 mg/mL and 3 mL makes 1.667 mg/mL. Choose the amount that puts your dose somewhere between about 10 and 40 units, where it's easiest to read.
Is AOD-9604 approved by the FDA?
No. FDA says AOD-9604 isn't a component of any FDA-approved drug. Its advisory committee voted 0 to 12 against allowing it in compounded drugs on December 4, 2024.
Does this page tell me how much AOD-9604 to take?
No. There's no FDA-approved AOD-9604 product, so there's no approved dose to point to. The dose box starts empty for that reason, and the chart only converts.
More peptide calculators by name
The same instrument, set up one peptide at a time. For any other vial, use the peptide reconstitution calculator.