What ipamorelin is
Ipamorelin is a peptide of five amino acids, some of them not found in nature. FDA's review gives the formula of the free base as C38H49N9O5 and its molecular weight as 711.85 g/mol.
Where it stands with the FDA
Ipamorelin isn't approved by the FDA, and the agency says it isn't a component of any FDA-approved drug. Two nominations asked for it to be allowed in compounded drugs.
FDA reviewed it for two uses, growth hormone deficiency and the slowed bowel that can follow surgery, and concluded that the criteria weigh against putting it on the list of substances pharmacies may compound with.
On October 29, 2024, FDA's Pharmacy Compounding Advisory Committee voted on it. For both the free base and the acetate, nobody voted in favor, 12 voted against and one member abstained.
The strength in the record
The product described in the nominations was a lyophilized powder for injection under the skin at 2,000 mcg/mL. FDA's review adds that the free base dissolves poorly in water, and that it's unclear how a 2 mg/mL injection could be made from it.
| Strength in the record | Water for a 5 mg vial | One unit holds | 10 units hold |
|---|---|---|---|
| 2,000 mcg/mL | 2.5 mL | 20 mcg | 200 mcg |
Add that much water to a 5 mg vial and it comes to that strength. Any other amount of water works too. It only changes how many units the same dose takes up.
Storing ipamorelin
FDA's review says ipamorelin is expected to be stable stored below -18°C, and repeats a report that the lyophilized powder is stable at room temperature for three weeks. Both describe the dry powder, not a mixed vial.
There's no approved label for ipamorelin, so nothing official says how long a mixed vial keeps.
Ipamorelin dosage calculator questions
How do I turn a ipamorelin dose into syringe units?
Divide the dose by the concentration to get millilitres, then multiply by 100. A 5 mg vial mixed with 2.5 mL is 2 mg/mL, so one unit on an insulin syringe holds 20 mcg and ten units hold 200 mcg.
How much bacteriostatic water goes in a 5 mg vial of ipamorelin?
There's no single right amount. The water only sets the concentration, and the amount of ipamorelin in the vial stays the same. With 5 mg, 1 mL makes 5 mg/mL, 2 mL makes 2.5 mg/mL and 3 mL makes 1.667 mg/mL. Choose the amount that puts your dose somewhere between about 10 and 40 units, where it's easiest to read.
Is ipamorelin approved by the FDA?
No. FDA says ipamorelin isn't a component of any FDA-approved drug. Its advisory committee voted on October 29, 2024, with no votes in favor of allowing it in compounded drugs, 12 against and one abstention.
Does this page tell me how much ipamorelin to take?
No. There's no FDA-approved ipamorelin product, so there's no approved dose to point to. The dose box starts empty for that reason, and the chart only converts.
More peptide calculators by name
The same instrument, set up one peptide at a time. For any other vial, use the peptide reconstitution calculator.